Breaking The Ice, Tissues first appeared amongst the Season 2 newbies, who have fallen out of the aeroplane. During some socializing, Tissues constant sickening conditions are made clear when he sneezes on Trophy. Before the first challenge begins, Tissues also displays a tendency to take things literally, as after a pun by Trophy about his middle name being "horseplay", Tissues gullibly believes this is true, and even calls him this during the challenge, as he attempts to form an alliance with Trophy, but fails horribly. After the challenge, Tissues is placed evenly on The Bright Lights. When the next challenge is revealed as dodge-ball, Tissues displays his displeasure with reference to his worsening condition, before sneezing yet again, this time on Soap. Tissues did not participate as much as others in the competition, not seen to throw as single ball on screen. His team ended up losing, and were put up for elimination.In Marsh on Mars, he was seen at elimination, sitting on a bench with the others, he didn't look particularly worried when it was declared he was in the bottom three, but was annoyed when MePhone4 called him disgusting. It is soon revealed he had 700 votes, leading to him getting eliminated. He was shocked when realizing lots of people voted for him. He was confused once MePhone4 mentioned the Rejection Portal. MePhone4 angrily commands him to go inside it. He then reminds them about his condition, then he quickly sneezes, landing him inside the portal. He hasn't been seen since his elimination.